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2017 Potential Applications of Polymer / Nanocrystalline Hydroxyapatite Based Scaffolds in Tissue Engineering: Effect of Porosity

In recent years, significant progress has been performed in designing and producing polymer/ceramic based 3D porous scaffolds for tissue engineering applications. Conventional metals used in hard tissue applications currently are unsatisfactory due to density and mechanical mismatch between the implant and the hard tissues. Therefore, implant materials with higher mechanical strength than bone result in stress shielding. Moreover, some components of these materials might be toxic under in-vivo conditions. Polymer/nano-hydroxyapatite composites are currently investigated to solve the problems arising from the conventionally used biometals. This study investigates the contribution of pore parameters (Total porosity, pore size, pore distribution, pore morphology) on various characteristics of scaffolds for hard tissue applications.

International Conference of Advanced Materials and Manufacturing Technologies
ICAMT

Zafer Evis

298 214
Subject Area: Materials Science Broadcast Area: International Type: Article Language: English
2017 Characterization and In Vitro Bioactivity of Multisubstituted Hydroxyapatite Nanopowders

Nano hydroxyapatite doped with different fractions of zinc (0-0.5 mole%), silver (0-0.5 mole%), magnesium (0-0.5 mole%) and sulphate (0-0.5 mole%) ions has been synthesized successfully and rapidly through microwave irradiation technique. The impact of dopants on the phase formation and microstructure of the powders were investigated using X-ray diffraction (XRD) technique. XRD analysis showed that with an incorporation of Zn2+, Ag+, Mg2+and SO42- ions into HA structure resulted in peak broadening and reduced peak height due to the amorphous nature and reduced crystallinity of the resulting HA powder. The in vitro bioactivity of all materials was evaluated by immersing the samples in the Simulated Body Fluid (SBF) over 14 days at 37 °C. FESEM and EDX analysis confirmed the formation of bonelike apatite with Ca/P ratio between 1.3-1.8 on the surface of the samples. FESEM images suggest that incorporation of multi-ions into the structure increased the surface reactivity of the samples and, as a result, a higher degree of apatite growth was observed for all doped samples. The materials obtained can be considered a promising material for coating of orthopedic and dental implants in surgical applications.

International Conference of Advanced Materials and Manufacturing Technologies
ICAMT

Ammar Z. Alshemary Zafer Evis

299 192
Subject Area: Materials Science Broadcast Area: International Type: Article Language: English
2017 Enhancement of Mechanical Properties of Co-Doped Hydroxyapatite Coatings on Pre-treated Ti6Al4V

Titanium and its alloys are commonly preferred implant materials for hard tissue applications. Today more than 4.4 million people have an internal fixation device and over 1.3 million people possess an artificial joint. Not only is there high demand for orthopedic surgeries for new patients every year, but there is also an even higher demand for patients who must receive revision surgeries. In order to enhance the properties of titanium based implant materials, different pretreatment and coating techniques are commonly used. Calcium-phosphate coatings are the most favorable method to upgrade the osteointegration properties of biomaterials. Porous structure of hydroxyapatite enables osteoblast attachment, proliferation and finally leads to osteointegration of the implant material. Biological performance of the coated implant can be improved by substitution of various ions. The goal of this study is to reduce implant rejection caused by the human body and increase the implants lifetime as this new generation orthopedic implants are produced. Mimicking the bone structure by coating metallic scaffold with co-doped Hydroxyapatite in effective way enable strong bone-implant integration. The aim is to prepare a new generation of coating on Ti6Al4V implant. Coated plates were evaluated in terms of their mechanical properties.

International Conference of Advanced Materials and Manufacturing Technologies
ICAMT

Tugce Hacioglu Zafer Evis Aysen Tezcaner

326 234
Subject Area: Materials Science Broadcast Area: International Type: Article Language: English