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2019 DEVELOPMENT OF BIOINK FOR BONE TISSUE ENGINEERING APPLICATIONS

Bioprinting technology, one of the three-dimensional printing technologies, is continuously developing with the studies carried out every day and it is becoming more important in the construction of functional tissue scaffolds with different properties in the field of tissue engineering. In the construction of tissue scaffolds, the studies on bioink which is component of bioprinters is very important. It is very important to study on production of processable bioink for production of tissue scaffolds with the desired mechanical, chemical, biological and surface properties and/or to be used for direct printing with cells. Properly printable bioink production will increase the possibility of using bioprinters in tissue engineering studies and will enable us to respond to the needs of tissue engineering. In this study, bioceramic powders based on calcium phosphate (CaP), poly(vinyl alcohol) (PVA) and different growth factors are used to produce a suitable bioink for use in bone tissue engineering applications. It is aimed to enable the printing of bone tissue with the bioprinters with desired feature of material produced in this project. This study provides a solution to the lack of bioink alternative for the professionals using the bioprinting method.

International Congress on 3D Printing (Additive Manufacturing) Technologies and Digital Industry
3D-PTC2019

Mert Gezek Fatih Çiftçi Cem Bülent Üstündağ

226 262
Subject Area: Engineering Broadcast Area: International Type: Article Language: English
2019 DRUG DESIGN WITH 3D PRINTER IN DIFFERENT ARCHITECTURES FOR DRUG DELIVERY SYSTEMS

Patients may face challenges of taking medication in good order. Implantable, biodegradable drug delivery systems are useful options with minimum side effects in these cases. A lot of parameters can be adjusted in the systems. The two main components of the systems are the active ingredient and the polymeric support material which supports the active ingredient. Poly(lactic acid) (PLA) is one of the suitable polymers as a support material for many different aspects. In addition to this, PLA can be easily printed by 3D printers. Therefore, one of the most promising technologies that can be used with the implantable biodegradable drug delivery system is 3D printer technology. Aim of this study is to offer implantable and biodegradable PLA that would be placed on the skin beneath as a drug support material with tailoring morphological features that drug is loaded in different architectures for implantable drug delivery systems, especially controlled drug delivery by using a 3D modeling program that is SolidWorks, and Fused Deposition Modeling (FDM) technology for 3D printing. Some of models were printed.

International Congress on 3D Printing (Additive Manufacturing) Technologies and Digital Industry
3D-PTC2019

Aleyna KUCUKAY Mert Gezek Cem Bülent Üstündağ

224 198
Subject Area: Engineering Broadcast Area: International Type: Article Language: English
2019 FILAMENT FABRICATION AND 3D PRINTING OF POLY(LACTIC ACID) AND CALCIUM SULFATE (PLA/CASO4) FOR BONE TISSUE ENGINEERING

Three-dimension(3D) printer using Fused Deposition Modeling (FDM) can be efficiently and quickly produced scaffold for the treatment of bone defects or injury. We carried out that bio-composite material(CaSO4/PLA) like natural bone substitute was obtained via extruder and biocomposite material filament in the ratio of 10:90 was produced to be suitable 3D-printer. Also, this work focused design of the 3D bone structure to print by using poly (lactic acid) (PLA) filament consist of about %10 Calcium Sulfate. The obtained bio-composite filament was characterized by thermogravimetric analysis (TGA) and Differential Scanning Calorimetry (DSC). Therefore, CaSO4/PLA scaffolds fabricated via FDM 3D-printer by using a filament.

International Congress on 3D Printing (Additive Manufacturing) Technologies and Digital Industry
3D-PTC2019

Ayse KAPLAN Fatih CIFTCI Mert Gezek Cem Bülent Üstündağ

244 227
Subject Area: Engineering Broadcast Area: International Type: Article Language: English
2019 MECHANICAL CHARACTERIZATION OF 3D PRINTED PLA TENSILE TEST SPECIMEN

In this study, the effect of the direction of the printing and annealing process on mechanical properties of 3D printed PLA samples were investigated based on fatigue performance. The tensile- fatigue properties of the tensile specimen which is produced from PLA by 3D printing in the face-up (X), edge-up (Y) and up-right (Z) direction were investigated in three different orientations. The elastic modulus was highest in the Y orientation and lowest in the Z orientation. In addition, the effect of annealing process on mechanical properties was investigated by applying annealing at 50 °C, 70 °C, 90 °C to the samples printed in the same direction (face-up). Mechanical properties increased with heat treatment. Mechanical strength was highest at 90 °C.

International Congress on 3D Printing (Additive Manufacturing) Technologies and Digital Industry
3D-PTC2019

Fatih CIFTCI Mert Gezek Cem Bülent Üstündağ

223 1017
Subject Area: Engineering Broadcast Area: International Type: Article Language: English